"Technical innovations in basic and translational Research in Immunology-Oncology".

The Institut Cancer et Immunologie (ICI) is offering Master's and PhD students the opportunity to take part in a mixed international mobility program on the theme of "Technical innovations in fundamental and translational research: Applications to immunology-oncology" at universities in the CIVIS alliance. Virtual mobility in the form of e-learning (webinars on Moodle) and 5-day physical mobility in high-tech laboratories and scientific platforms, will enable students to discover or deepen their skills in Immuno-Oncology.

  1. Cytometry (mass, flow and spectral):
    • Multi-color flow cytometry for phenotypic characterization of tumor-infiltrating T lymphocytes, Silvia Piconese, Sapienza Università di Roma
    • Real-time cellular analysis in immuno-oncology, Mihaela Economescu, Stefan S. Nicolau Institute of Virology, Bucharest Romania
    • Multiparametric flow cytometric analysis for phenotypic characterization of age-associated changes in circulating Tcell subsets, Maria Mittelbrunn, Universidad Autonoma de Madrid
    • Evaluation of neutrophil functions in the tumor microenvironment, Luminita Marutescu, University of Bucharest
    • Cancer immunomonitoring - NK cells and cancer, Gratiela Gradisteanu, University of Bucharest
    • Detection of immune checkpoints and their ligands in the tumor environment by multicolor flow cytometry, Lilia Matei, Stefan S. Nicolau Institute of Virology, Bucharest (Romania)
    • Evaluation of immune function in tumors using xMAP multiplex technology, Coralia Bleotu, Stefan S. Nicolau Institute of Virology, Bucharest Romania
    • Multicolor imaging flow cytometry for the characterization of cancer response to drug treatments, Cristina Elena Staicu, National Institute of Laser, Plasma and Radiation Physics, University of Bucharest; Livia Elena Sima, Institute of Biochemistry of the Romanian Academy
    • Mass cytometry - Principles and applications, Amira A Ben Amara, Aix-Marseille Université
    • Spectral flow cytometry, Manon Richaud, Institut Paoli Calmettes, CRCM, Aix Marseille Université
    • Computational methods for flow and mass cytometry data analysis, Anne-Sophie Chretien, Aix-Marseille Université.
  2. Organoids :
    • Organoids: New biological models for developmental biology and cancer research, Géraldine Guasch, CRCM, Aix-Marseille Université.
    • Ex vivo culture of organoids for personalized and regenerative medicine, Marie Isabelle Garcia, Université Libre de Bruxelles
    • In vitro 3D models of the human nervous system: challenges and opportunities, Alessandro Rosa, Sapienza Università di Roma
    • In vitro assessment of cellular energy metabolism and cell growth, Petronila Penela ; Angela Albitre; Laura Formentini, Universidad Autónoma de Madrid
    • Animal models for tumor immunology/mouse models for cancer immunotherapy research, Catalina Ribas; Kostas Stamatakis ; María Sanz, Universidad Autónoma de Madrid.
  3. Genomics (CRSPR, RNAseq and TCRseq):
    • Functional genomics using CRISPR screening, Sandrine Roulland, Aix-Marseille Université
    • DNA microarrays and RNAseq in cancer transcriptomics, Rodolfo Negri, Sapienza Università di Roma
    • Single-cell RNA-seq (scRNAseq), Pierre Milpied, CIML, Aix-Marseille Université
    • TCR/CDR3 sequencing: insights into T-cell development and anti-cancer response, David Vermijlen, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles
    • Hands-on Introduction to RNA-Seq, Sumeet Pal Singh, IRIBHM, Université Libre de Bruxelles
  4. Proteomics:
    • Protein analysis by mass spectrometry, Marco Crescenzi, Sapienza Università di Roma, Istituto Superiore di Sanità ; Serena Camerini, Istituto Superiore di Sanità
    • Characterization of IgG glycosylation and its impact in cancer and immunology, Cédric Delporte; Yosra Helali, Université Libre de Bruxelles
    • Reverse-phase protein arrays: Identification of protein biomarkers of disease, José M. Cuezva, Universidad Autónoma de Madrid
    • Targeted proteomics: Development of quantitative proteomics based on parallel reaction monitoring (PRM) applied to her2-positive breast cancer, Luc Camoin, Aix Marseille Université
    • Maldi imaging and therapeutic antibodies: application to glioma, Daniel Lafitte, Aix-Marseille Université
  5. Microscopy-Imaging
    • Cryo-electron microscopy (Cryo-EM) for the study of fine cellular structures and protein complexes in immune cells and cancer cells, Luciana Dini, Sapienza Università di Roma
    • 3D structured illumination microscopy for the study of nuclear integrity and cancer invasion, Isabella Saggio, Sapienza Universita di Roma
    • Spatio-temporal organization of macromolecular complexes involved in lymphocyte signaling, Didier Marguet, CIML, Aix-Marseille Université
    • Isolation and characterization techniques for the study of exosomes, María Yáñez-Mó, Universidad Autónoma de Madrid ; Mar Valés-Gómez; Noa Martín Cofreces

The host laboratories for the physical part are listed below. This section will enable students to put into practice what they have learned in the virtual section.

  • Paula Michea, Aix-Marseille Université (AMU), Institut Cancer et Immunology (ICI), Marseille Faculty of Science, Marseille Cancer Research Center (CRCM)
  • Marie-dominique Franco, Project Manager, Institute of Cancer and Immunology (ICI, AMU)
  • Luminita Marutescu, University of Bucharest, Faculty of Biology, Department of Biotechnology and Renewable Resources, Systems Biology and Ecology Research Platform.
  • Catalina Ribas and María Yánez Mo, Autonomous University of Madrid, Faculty of Science, Department of Molecular Biology.
  • Loretta Tuosto, Sapienza Università di Roma, Faculty of Mathematical, Physical and Natural Sciences, Charles Darwin Department of Biology and Biotechnology (BBCD).
  • David Vermijlen, ULB Center for Research in Immunology (U-CRI), Faculty of Pharmacy, Department of Pharmacotherapy and Pharmacy and Center for Research in Immunology.
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